What Is Atovaquone/Proguanil 250mg/100mg?

Atovaquone/Proguanil is a combination antimalarial tablet commonly used by travellers and healthcare professionals to prevent and treat malaria infections. It contains atovaquone and proguanil hydrochloride, two ingredients that work together to fight the malaria parasite in the bloodstream.

What Is Atovaquone/Proguanil Used For?

This medicine is used to help prevent malaria in high-risk areas and to treat uncomplicated malaria if an infection occurs.

It’s a trusted option for:

• Malaria prevention: Taken before, during, and after travel to areas with a high malaria risk.
• Treatment of malaria: Used for mild to moderate cases of Plasmodium falciparum malaria.
• Preferred choice: Due to its short post-travel dosing period and good tolerance in adults and children over 40 kg.

How Does Atovaquone/Proguanil Work?

Atovaquone/Proguanil works by disrupting the parasite’s life cycle, preventing it from multiplying and spreading in the blood. Together, the two active ingredients stop the malaria parasite from reproducing and help the body fight off infection more effectively.

How Should Atovaquone/Proguanil Be Taken?

Follow your doctor’s instructions carefully to get the best protection or treatment results.

• For prevention: Take one tablet once daily, starting 2 days before entering a malaria zone, during your stay, and for 7 days after leaving.
• For treatment: Take exactly as prescribed. The dosage may differ based on your weight and the severity of infection.
• With food: Always take with food or a milky drink to improve absorption.
• Timing: Take at the same time each day, if possible.

Are There Any Side Effects?

Like all medicines, Atovaquone/Proguanil may cause side effects, although not everyone gets them.

• Common side effects: Headache, abdominal pain, loss of appetite, nausea, or diarrhoea.
• Less common: Fever, skin rash, insomnia, or dizziness.
• Serious reactions: Allergic reactions are rare but require immediate medical attention.
• Seek advice: Speak to a doctor if symptoms are severe or don’t go away.

What Warnings and Precautions Should Be Considered?

Make sure this medicine is suitable for you before starting treatment or prevention.

• Do not take if you are allergic to atovaquone or proguanil.
• Avoid if you have severe kidney problems — your doctor may suggest a different option.
• Not usually recommended for pregnant or breastfeeding women.
• Inform your doctor if you’re taking other medications, particularly antibiotics, rifampicin, or blood thinners, as they may interact.

How Should Atovaquone/Proguanil Be Stored?

Proper storage helps keep your medicine safe and effective.

• Store in a cool, dry place below 30°C.
• Keep tablets in their original packaging until you’re ready to use them.
• Keep out of sight and reach of children.
• Do not take after the expiry date printed on the packaging.