Tadalafil vs Sildenafil – What Do You Need to Know in 2025
07/Feb
Erectile dysfunction (ED) affects up to one in five men in the UK, impacting around 4.3 million individuals. However, this figure may be an underestimation, as many men hesitate to seek medical help, leading to under-reporting. In fact, some studies suggest the true prevalence could be as high as 41%—nearly two in five men.
Two of the most popular medications for ED are Tadalafil and Sildenafil. While both belong to the same drug class and work similarly, they have distinct differences in effectiveness, duration, and side effects. This blog provides a detailed comparison to help you make an informed decision.
What is Tadalafil?
Tadalafil is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). It belongs to a class of drugs called PDE5 inhibitors, which work by relaxing blood vessels to improve blood flow.
For erectile dysfunction, Tadalafil helps men achieve and maintain an erection by increasing blood flow to the penis when sexually stimulated. Unlike some other ED medications, it has a longer duration of action—lasting up to 36 hours—earning it the nickname the weekend pill.
For benign prostatic hyperplasia (BPH), Tadalafil helps relieve symptoms such as difficulty urinating by relaxing the muscles in the prostate and bladder.
It is available in different doses, including daily low-dose options for continuous effectiveness or higher doses for use as needed. Tadalafil is the active ingredient in Cialis, a well-known ED medication, but is also available as a generic drug.
What is Sildenafil?
Sildenafil usually known as Viagra is a medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It belongs to a class of drugs known as PDE5 inhibitors, which work by relaxing blood vessels and increasing blood flow.
For erectile dysfunction, Sildenafil helps men achieve and maintain an erection when sexually stimulated by improving blood flow to the penis. It is the active ingredient in Viagra, one of the most well-known ED medications.
For pulmonary arterial hypertension (PAH), Sildenafil helps lower blood pressure in the lungs, making it easier for the heart to pump blood.
Sildenafil is not an aphrodisiac and does not increase sexual desire. It only works when there is sexual stimulation. It should not be taken with nitrates (used for heart conditions) or certain other medications due to the risk of a severe drop in blood pressure. Always consult a healthcare professional before use.
Tadalafil vs Sildenafil In a Nutshell
Sildenafil vs Tadalafil: What’s the Difference?
Sildenafil and Tadalafil are two of the most common medications used to treat erectile dysfunction (ED). Both belong to a class of drugs known as PDE5 inhibitors, which work by relaxing blood vessels and increasing blood flow to the penis.
While they have similar functions, there are key differences in how they work, how long they last, and when they should be taken.
1. How Long They Last?
Sildenafil (Viagra): Lasts 4–6 hours
Tadalafil (Cialis): Lasts up to 36 hours
Note: Tadalafil is known as ‘the weekend pill’ because its effects can last much longer than Sildenafil.
2. How Quickly They Work?
Sildenafil: Takes effect in 30–60 minutes
Tadalafil: Takes effect in 30 minutes–2 hours, but some users may notice results sooner
Pro tip: Both should be taken about an hour before sex, but Tadalafil’s longer duration offers more flexibility.
3. How Are They Taken?
Sildenafil: 25-100mg, taken as needed
Tadalafil: 10-20mg for as-needed use; 5mg daily
Pro tip: Daily Tadalafil is a good option for men who want more spontaneity without planning around medication.
4. Effectiveness
Both medications are highly effective for ED, but Tadalafil may offer a more natural experience due to its longer window of action.
Pro tip: For men who want an erection on demand, Sildenafil may be better. For those who prefer long-lasting effects, Tadalafil is ideal.
5. Side Effects
Both medications share common side effects, such as:
- Headache
- Flushing
- Nasal congestion
- Indigestion
- Dizziness
Note: Tadalafil may be more likely to cause muscle or back pain, while Sildenafil may lead to temporary vision changes.
Tadalafil vs Sildenafil: Dosage Schedule
Choosing the right dose of sildenafil or tadalafil depends on how your body responds and how often you need it. Here’s a guide to help you understand how much to take and when.
Sildenafil (Viagra) – Short-Acting, As Needed
Starting dose: 50mg
When to take it: Around one hour before sex
Adjustment: Can be increased to 100mg or lowered to 25mg depending on effectiveness and tolerance
Maximum dose: 100mg per day (never exceed this limit)
Duration of effect: 4–6 hours
Frequency: Once per day maximum
Important: Sildenafil works best on an empty stomach. Taking it with a heavy meal, especially one high in fat, may delay its effect.
Tadalafil (Cialis) – Longer-Lasting, Flexible Use
As-needed dose: 10mg at least 30 minutes before sex
Adjustment: Can be increased to 20mg or lowered to 10mg based on response
Maximum dose: 20mg per day
Duration of effect: Up to 36 hours
Frequency: Once per day maximum if taken as needed
Daily Use (for frequent sex):
Starting dose: 2.5mg to 5mg daily
How it works: Builds up in your system over a few days, allowing for spontaneous sexual activity
Best for: Those who have sex multiple times per week
Key Advantage: Tadalafil stays in your body longer, giving you a wider window for intimacy rather than needing to plan around a short timeframe.
Tadalafil vs Sildenafil: Which One is Best for You?
When choosing between sildenafil (Viagra) and tadalafil (Cialis), the decision often comes down to what matters most to you.
A study comparing the two found that sildenafil provided slightly firmer peak erections for some men. However, tadalafil offered a longer-lasting effect, which many participants preferred as it gave them more flexibility rather than a short window of peak performance.
So, the choice is simple:
– If you prioritise maximum firmness, sildenafil might have a slight edge.
– If you want a longer window of opportunity, tadalafil is likely the better fit.
There’s no one-size-fits-all answer—results vary from person to person. The best way to decide is to consider your needs, lifestyle, and how your body responds to each medication.
Consult with The Care Pharmacy for Your Erectile Dysfunction
If you’re struggling with erectile dysfunction, you’re not alone. At The Care Pharmacy, we offer discreet and professional support to help you find the right treatment while ensuring your privacy and well-being.
Our secure online platform makes it easy to access consultations and personalised ED treatments. Simply complete a short, confidential self-assessment to explore suitable options such as Sildenafil or Tadalafil.
You’ll receive a tailored treatment plan once reviewed by our UK-registered clinical team. If prescribed, your medication will be delivered directly to your door in discreet packaging, ensuring a hassle-free and private experience.
Take the first step towards restoring confidence and improving your sexual health today.
FAQs
Which is better Tadalafil or Sildenafil?
Tadalafil is just as effective as sildenafil in treating erectile dysfunction. However, comparison studies suggest that many men prefer Tadalafil over Sildenafil (50/100mg), likely due to its longer-lasting effects. With its extended duration of action, Tadalafil is increasingly becoming the preferred choice among phosphodiesterase inhibitors and may eventually overtake sildenafil as the go-to treatment for ED.
Is 20 mg Tadalafil equal to 100mg Viagra?
No, 20mg of Tadalafil is not the same as 100mg of Sildenafil (Viagra). While both medications treat erectile dysfunction (ED) by increasing blood flow to the penis, they work differently in terms of onset, duration, and effectiveness.
Does Tadalafil keep you hard after ejaculation?
No, Tadalafil does not keep you hard after ejaculation. It helps with erections when sexually stimulated but does not override the natural refractory period after ejaculation. However, it may reduce the time needed to get another erection.
Which pill is stronger Viagra or Cialis?
It depends on how you define “stronger.”
Viagra (Sildenafil) tends to provide a stronger peak erection for a shorter period (4–6 hours).
Cialis (Tadalafil) lasts much longer (up to 36 hours) but may not produce the same peak firmness as Viagra.
If you want maximum short-term potency, Viagra (sildenafil) 100mg is stronger. If you prefer longer-lasting effects, Cialis (tadalafil) 20mg is more effective.
What is the strongest erectile dysfunction medicine?
The strongest erectile dysfunction (ED) medication depends on dosage, duration, and effectiveness for the individual. Here’s a breakdown of the most potent options:
Sildenafil (Viagra) – Up to 100mg
- Provides a strong, short-term effect
- Lasts 4–6 hours
- Best for peak firmness
Tadalafil (Cialis) – Up to 20mg
- Lasts up to 36 hours (longest duration)
- Allows for more natural, spontaneous activity
Vardenafil (Levitra) – Up to 20mg
- Similar to Viagra but may work better for some men
- Lasts 4–6 hours
Avanafil (Stendra) – Up to 200mg
- Fastest onset (as quick as 15 minutes)
- Lasts 6–12 hours
Medically reviewed by
Mohammed Lakhi
Superintendent Pharmacist
No GP Appointments Needed
